摘要 |
Arylalkylamines of formula: …<IMAGE>… in which: … … - Y denotes … - either a group Cy-N in which: … … Cy denotes an optionally substituted phenyl, a C3-C7 cycloalkyl, a pyrimidinyl or a pyridyl, … … - or a group …<IMAGE>… in which … … Ar denotes an optionally substituted phenyl, a pyridyl or a thienyl, … x is zero or one, … X denotes especially a hydroxyl, a C1-C4 alkoxy, a C1-C4 acyloxy, a carboxyl, a C1-C4 carbalkoxy, a cyano, a group -N-(X1)2 in which the groups X1 independently denote hydrogen or a C1-C4 alkyl, a group -S-X2 in which X2 denotes hydrogen or a C1-C4 alkyl group, a group …<IMAGE>… in which Alk is a C1-C6 alkyl, or else X forms a double bond with the carbon atom to which it is bonded and with the neighbouring carbon atom in the heterocyclic ring, … … - m is 2 or 3, … - Ar' denotes an optionally substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl, … - R denotes hydrogen or a C1-C6 alkyl, … - T denotes a group chosen from -CO- and -CW-NH-, W being an oxygen or sulphur atom, and … - Z denotes either hydrogen or M or OM when T denotes the group -CO-, or M when T denotes the group -CW-NH-, M denotes a C1-C6 alkyl, a phenylalkyl, a pyridylalkyl, a naphthylalkyl, a pyridylthioalkyl, a styryl or an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group, … or one of its salts with inorganic or organic acids. … …<??>Application: antagonists of neurokinin receptors. |