发明名称 |
(ARYL OR HETEROAROMATIC METHYL)-2,2'-BI-1H-IMIDAZOLES |
摘要 |
This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or nonsubstituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
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申请公布号 |
CA1338786(C) |
申请公布日期 |
1996.12.10 |
申请号 |
CA19880572886 |
申请日期 |
1988.07.22 |
申请人 |
MERRELL DOW PHARMACEUTICALS (CANADA) INC. |
发明人 |
MATTHEWS, DONALD P.;WHITTEN, JEFFREY P.;MCCARTHY, JAMES R. |
分类号 |
A61K31/415;A61K31/425;A61P9/12;C07D233/54;C07D233/60;C07D233/64;C07D405/06;C07D405/14;C07D409/06;C07D409/14;C07D417/14;(IPC1-7):C07D403/04 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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