| 摘要 |
PURPOSE: To obtain a methotrexate derivative-containing medicine effective for glomerular nephritis and autoimmunity diseases such as systemic lupus erythematosus. CONSTITUTION: A methotrexate derivative-containing medicine contains a compound of the formula (R1 is CH2 , CH2 CH2 , CH2 O, CH2 S, CH2 SO; R2 is H, a 1-4C lower alkyl, benzyl; R3 is COOR4 , NHCOR5 , CONR6 R7 , PO3 H2 , SO3 H; R4 is H, a lower alkyl; R5 is phenyl; R6 is H, a lower alkyl; R7 is a lower alkyl, phenyl, etc.; n is 1-4) or its salt as an active ingredient. The medicine may orally or parenterally be administered, but the oral administration is preferable. The administration dose of the medicine is 0.01-100mg/day/adult. The compound of the formula includes N-(1-((2,4-diamino-6-pteridinyl)methyl) methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl)-L-α-aminoadipic acid.
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