| 发明名称 |
Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| 摘要 |
PCT No. PCT/US93/04804 Sec. 371 Date Dec. 16, 1994 Sec. 102(e) Date Dec. 16, 1994 PCT Filed May 24, 1993 PCT Pub. No. WO93/23388 PCT Pub. Date Nov. 25, 1993A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
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| 申请公布号 |
US5583238(A) |
申请公布日期 |
1996.12.10 |
| 申请号 |
US19940290976 |
申请日期 |
1994.12.16 |
| 申请人 |
G. D. SEARLE & CO. |
发明人 |
NG, JOHN S.;PRZYBYLA, CLAIRE A.;MUELLER, RICHARD A.;VAZQUEZ, MICHAEL L.;GETMAN, DANIEL P. |
| 分类号 |
A61K31/17;A61K31/195;A61K31/197;A61K31/216;A61K31/27;A61K31/47;A61K31/4709;A61K31/496;A61K31/5377;A61K38/00;C07C213/00;C07C213/02;C07C213/08;C07C215/28;C07C269/06;C07C271/16;C07C271/20;C07C271/22;C07C275/14;C07C275/18;C07C275/22;C07C275/24;C07C275/28;C07C311/47;C07C317/44;C07C317/50;C07C323/60;C07C329/06;C07C335/08;C07C335/12;C07D213/81;C07D215/48;C07D215/50;C07D215/54;C07D217/26;C07D235/06;C07D235/24;C07D239/38;C07D241/44;C07D295/13;C07D295/15;C07D303/36;C07D307/85;C07D401/12;C07K5/02;C07K5/06;C07K5/078;(IPC1-7):C07D301/00;C07D209/48 |
主分类号 |
A61K31/17 |
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