PRODUCTION OF ORGANIC COMPOUND LABELED WITH FLUORINE RADIOISOTOPE

摘要

PURPOSE: To produce a [<18> F]-labeled organic compound in high yield and at a low cost while keeping high collection efficiency of a [<18> F]-fluoride ion by using a phosphonium resin. CONSTITUTION: A labeled organic compound of the formula<18> FR is produced by (A) contacting a below mentioned resin with a [<18> F]-fluoride ion-containing water to collect a [<18> F]-fluoride ion on the resin, (B) activating the collected [<18> F]-fluoride ion by contacting the resin with the first polar neutral solvent and (C) contacting the treated resin with a solution containing a substrate of the formula XR (X is a nucleophobic leaving group; R is an alicyclic or an aromatic hydrocarbon group) dissolved in the second polar neutral solvent to react the substrate with [<18> F]-fluoride ion. The resin used in the process A is expressed by the formula [the ring P is a crosslinked alkylstyrene halide- styrene copolymer carrier; Y is an alkyl; Z is a counter ion; (n) is an integer of 1-7] and the content of the phosphonium salt is 0.5-1.6mmol/g. Further, at least one of the solvents is preferably acetonitrile.