发明名称 |
25-Carboxylic acid derivatives in the vitamin D series, process for their production, intermediate products for these processes, pharmaceutical preparations containing these derivatives as well as their use for the production of pharmaceutical agents |
摘要 |
New 25-carboxylic acid derivatives of general formula I, <IMAGE> (I) R19 and R19a each mean a hydrogen atom or together form an exocyclic methylene group, R21 and R21a independently of one another mean a hydrogen atom, a chlorine or fluorine atom, an alkyl group with 1 to 4 carbon atoms, together a methylene group, together with quaternary carbon atom 20 mean a 3-7 membered, saturated or unsaturated carboxylic ring, Y preferably means a derivatized carboxyl radical, and the other substituents have the meanings indicated in the description as well as process for their production, are described. The new compounds have vitamin D activity as well as proliferation-inhibiting and cell-differentiating effects and are suitable for the production of pharmaceutical agents.
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申请公布号 |
US5583125(A) |
申请公布日期 |
1996.12.10 |
申请号 |
US19930132176 |
申请日期 |
1993.10.06 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
STEINMEYER, ANDREAS;NEEF, GUENTER;KIRSCH, GERALD;SCHWARZ, KATICA;THIEROFF-EKERDT, RUTH;WIESINGER, HERBERT;HABEREY, MARTIN |
分类号 |
A61K31/59;A61P3/02;A61P3/08;A61P11/00;A61P17/00;A61P31/12;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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