发明名称 |
Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. |
摘要 |
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming alpha-helical or beta-sheet segments. In particular, amino acid residues known to stabilize alpha-helical and beta-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided. |
申请公布号 |
NL1003284(A1) |
申请公布日期 |
1996.12.09 |
申请号 |
NL19961003284 |
申请日期 |
1996.06.06 |
申请人 |
ALZA CORPORATION |
发明人 |
LESLIE ALLEN HOLLADAY;KEVIN RAY OLDENBURG |
分类号 |
C12N15/09;A61K9/00;A61K38/00;A61K38/22;A61K38/55;A61N1/30;C07K1/107;C07K14/635;C07K14/815 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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