| 摘要 |
<p>PURPOSE: To obtain the subject new factor, which is a polypeptide having a specific amino acid sequence, activities in proliferating a hematopoietic cell, especially a bone marrow cell and further immunomodulating and hematopoietic regulating functions and useful for treatment, etc., of immunodeficiency, autoimmune diseases, infectious diseases, cancers, etc. CONSTITUTION: This new human hematopoietic cell growth potentiating factor is a polypeptide, having an amino acid sequence represented by any of formulas I to III and capable of manifesting activities in proliferating a human hematopoietic cell, especially a bone marrow cell. The factor has immunomodulating and hematopoietic regulating functions, can be applied to treatment, etc., of immunodeficiency, infectious diseases, cancers, hepatitises, nephritides, bone marrow transplantation, etc., and is further effective in potentiating effects and reduction, etc., in adverse effects of other medicines by using thereof with other immunologically active substances, immunotherapeutic agents, lymphokines, cytokinins, interferons, cell growth factors, chemotherapeutic agents, antibiotic substances or antiviral agents in combination. This factor is obtained by isolating an mRNA from a monocytic cell derived from a human peripheral blood, preparing a cDNA library, screening the resultant cDNA library and expressing the resultant gene in a host cell.</p> |
