THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE

摘要

The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of an .alpha.1C selective agonist which activates a human .alpha.1C adrenoceptor at least ten-fold more than it activates a human .alpha.1A adrenoceptor and a human .alpha.1B adrenoceptor. The present invention further provides a method of inducing contraction of urethra and bladder neck tissues which comprises contacting the urethra and bladder neck tissues with an effective contraction-inducing amount of an .alpha.1C selective agonist which activates a human .alpha.1C adrenoceptor at least tenfold more than it activates a human .alpha.1A adrenoceptor and a human .alpha.1B adrenoceptor. In addition, the invention includes compounds for the treatment of urinary incontinence and for use in inducing contraction of urethra and bladder neck tissues.