发明名称 |
METHOD FOR THE DETECTION OF COMPOUNDS THAT MODULATE THE EFFECTS OF THE OBESE PROTEIN |
摘要 |
A method for the detection of a compound that mimics, potentiates or inhibits the physiological effect of the ob-protein, which method comprises: (a) for a compound which mimics the physiological effect of the ob-protein, assessing the effect of the compound upon an ob-protein activated signal transducer and activator of transcription (STAT) DNA response element coupled to a reporter gene; or (b) for a compound which potentiates or inhibits the physiological effect of the ob-protein assessing the effect of the compound upon the response provided by ob-protein upon an ob-protein activated STAT DNA response element coupled to a reporter gene; the response element and the reporter being expressed in an ob-protein responsive cell line; a kit of parts adapted for use in such method and a compound when identified by such method.
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申请公布号 |
CA2222409(A1) |
申请公布日期 |
1996.12.05 |
申请号 |
CA19962222409 |
申请日期 |
1996.05.28 |
申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
SMITH, RICHARD ANTHONY GODWIN;BEELEY, LEE JAMES |
分类号 |
C07K14/575;C12Q1/68;(IPC1-7):C12Q1/02;C12Q1/48;C12Q1/66 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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