摘要 |
<p>Novel fused polycyclic heterocycle derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have an excellent antitumor effect, and a process for producing the same, wherein the ring A represents an optionally substituted monocyclic aromatic ring or a fused bicyclic ring wherein at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-dioxane, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted monocyclic or fused bicyclic aromatic ring; and Y represents -e-f (wherein e represents lower alkylene; and f represents amidino, guanidino, or amino optionally substituted by hydroxy or lower alkyl optionally lower-alkylaminated); excluding a combination wherein the rings A and C are each an optionally substituted monocyclic aromatic ring.</p> |
申请人 |
EISAI CO., LTD.;SUGUMI, HIROYUKI;NIIJIMA, JUN;KOTAKE, YOSHIHIKO;OKADA, TOSHIMI;KAMATA, JUN-ICHI;YOSHIMATSU, KENTARO;NAGASU, TAKESHI;NAKAMURA, KATSUJI;UENAKA, TOSHIMITSU;YAMAGUCHI, ATSUMI;YOSHINO, HIROSHI;KOYANAGI, NOZOMU;KITO, KYOSUKE |
发明人 |
SUGUMI, HIROYUKI;NIIJIMA, JUN;KOTAKE, YOSHIHIKO;OKADA, TOSHIMI;KAMATA, JUN-ICHI;YOSHIMATSU, KENTARO;NAGASU, TAKESHI;NAKAMURA, KATSUJI;UENAKA, TOSHIMITSU;YAMAGUCHI, ATSUMI;YOSHINO, HIROSHI;KOYANAGI, NOZOMU;KITO, KYOSUKE |