METHOD FOR THE MANUFACTURE OF BENZOTHIAZEPINE DERIVATIVES
摘要
<p>A process for the manufacture of Diltiazem or deacetyl-Diltiazem, which comprises N-alkylation of the corresponding lactam with a suitable 2-(N,N-dimethylamino)ethyl derivative, using methyl isobutyl ketone as solvent and NaOH as base.</p>
