| 发明名称 |
NOVEL POLYMORPHS OF LESOPITRON DICHLOROHYDRATE AND ITS HYDRATED FORMS, PREPARATION METHODS AND COMPOSITIONS CONTAINING THEM |
| 摘要 |
The invention relates to the novel polymorphs (I and II) of dichlorohydrate of lesopitron, which are characterized by their X-ray diffractograms and infrared spectra. They are obtained by crystallization of lesopitron dichlorohydrate. It also relates to the forms I-hydrate and II-hydrate which are obtained from the corresponding polymorphs, and which have a water content from 3 to 6 % and from 1.5 to 2.5 %, respectively. Such products are useful in human medicine, essentially for their pharmacological activity on the central nervous system.
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| 申请公布号 |
CA2196425(A1) |
申请公布日期 |
1996.12.05 |
| 申请号 |
CA19962196425 |
申请日期 |
1996.05.29 |
| 申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
LUPON ROSES, PILAR;TOMAS NAVARRO, JAIME;PUIG TORRES, SALVADOR;FRIGOLA CONSTANSA, JORDI |
| 分类号 |
C07D403/14;A61K31/505;A61K31/506;A61P1/08;A61P25/00;A61P25/22;A61P25/24;A61P25/26;C07D237/00;C07D239/00;C07D295/00;C07D403/12;(IPC1-7):C07D403/12 |
主分类号 |
C07D403/14 |
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