发明名称 |
METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID |
摘要 |
The present invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid which comprises condensing isovaleraldehyde with an alkyl cyanoacetate to form a 2-cyano-5-methylhex-2-enoic acid alkyl ester; reacting the 2-cyano-5-methylhex-2-enoic acid alkyl ester with a dialkyl malonate to form 3-isobutylglutaric acid; forming the anhydride of 3-isobutylglutaric acid; reacting the anhydride with ammonia to form (+/-)-3-(carbamoylmethyl)-5-methylhexanoic acid; reacting (+/-)-3-(carbamoylmethyl)-5-methylhexanoic acid with (R)-(+)- alpha -phenylethylamine to obtain the (R)-(+)- alpha -phenylethylamine salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid; combining the salt with an acid to obtain (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid; and reacting the (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid with a Hofmann reagent to obtain (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid.
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申请公布号 |
WO9638405(A1) |
申请公布日期 |
1996.12.05 |
申请号 |
WO1996US05831 |
申请日期 |
1996.04.26 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
HUCKABEE, BRIAN, KEITH;SOBIERAY, DENIS, MARTIN |
分类号 |
C07C227/18;C07C211/27;C07C227/32;C07C229/08;C07C233/05;(IPC1-7):C07C227/32 |
主分类号 |
C07C227/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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