NOVEL NAPHTHYRIDINE DERIVATIVES

摘要

Naphthyridine derivatives represented by general formula (1) and acid-addition salts thereof, having the activity of inhibiting acyl CoA: cholesterol acyltransferases, and useful for preventing and treating hyperlipemia, arteriosclerosis and related diseases. In said formula, ring A represents an optionally substituted pyridine ring; X represents -NR<2>-CO-; R<2> represents hydrogen, alkyl, substituted alkyl, etc.; Z represents a bond, -NH-, C1-C2 alkylene, or -CH=CH-; Y represents alkyl, substituted alkyl, aryl, substituted aryl, etc.; and B represents alkyl, substituted alkyl, aryl, substituted aryl, etc.