发明名称 |
Process to activate sulfated polysaccharides |
摘要 |
The present specification is directed to a novel process to prepare an activated sulfated polysaccharide which may then be used in subsequent reactions or processes to bind the reactive polysaccharide with a nucleophilic agent or an aminated surface. The activating process comprises the steps of initially forming a polysaccharide tetraalkylammonium salt by contacting an aqueous mixture of a sulfated polysaccharide salt with a cation exchange resin to give a polysaccharide free acid and then contacting the polysaccharide free acid with a tetraalkylammonium hydroxide to give the polysaccharide tetraalkylammonium salt, and subsequently forming an activated sulfated polysaccharide by contacting the polysaccharide tetraalkylammonium salt of step i) with a coupling reagent in an aprotic organic solvent at ambient temperatures for a period of time sufficient to form the activated sulfated polysaccharide. |
申请公布号 |
AU5670996(A) |
申请公布日期 |
1996.11.29 |
申请号 |
AU19960056709 |
申请日期 |
1996.05.01 |
申请人 |
MINNESOTA MINING AND MANUFACTURING COMPANY |
发明人 |
MASAO YAFUSO;ROBERT J LINHARDT |
分类号 |
A61L33/00;A61L33/08;C08B37/00 |
主分类号 |
A61L33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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