| 摘要 |
A process for preparing 10b-methyl-3-oxo-benzoÄfÜ quinolines of the formula <CHEM> wherein R is methylthio, and is located at the 7-, 8- or 9-position; comprising reacting a compound of the formula <CHEM> with methyl iodide in an ether solvent to prepare a compound of the formula <CHEM> combining acrylic anhydride or acryloyl chloride with the reaction mixture comprising the compound of formula III to prepare a compound of the formula <CHEM> quenching the reaction with sodium bicarbonate, evaporating the organic solution comprising the compound of formula IV; and combining the residue comprising the compound of formula IV with a trialkylsilane and trifluoroacetic acid in the absence of a solvent to prepare the compound of formula I. |
