| 摘要 |
In accordance with the present invention, there are provided modulators for orphan member(s) of the steroid/thyroid superfamily of receptors which is related to the previously described CAR- alpha . Thus, compounds of the general class of androstans have been identified as modulators for a newly discovered isoform of CAR. Compounds discovered in accordance with the present invention can be employed in a variety of applications, e.g., for the modulation of processes mediated by an isoform of CAR or CAR-like species, to increase the libido of a subject (especially a subject undergoing therapy using a 5 alpha -reductase inhibitor), in a screening assay for the presence of receptors involved in the modulation of libido, and the like. Also provided in accordance with the present invention are methods for the identification of compounds which modulate processes mediated by an isoform of CAR or CAR-like species, as well as novel compositions derived therefrom. |
