2-hydroxyphenylalkylamine derivatives and maillard reaction inhibitors

摘要

The present invention relates to a 2-hydroxyphenyl alkylamine derivative represented by the general formula: wherein R<1>, R<2>, R<3> and R<4> are the same or different: and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group, a mercapto group, a halogen atom, a nitro group, an amino group, an acylamino group, an acyl group or a hydroxy(lower alkyl) group; R<5> represents a hydrogen atom or a lower alkyl group; A represents a single bond, a lower alkylene group which may have a hydroxy group as a substituent or a lower alkenylene group; Y represents a single bond or a lower alkylene group; and Z represents a carboxyl group, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl group etc. and a pharmaceutically acceptable salt thereof which have a Maillard reaction inhibiting activity.