The invention provides a purified human 38 kD beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells lying in pancreatic islets of Langerhans, which protein contains an epitope recognized by T cell clone 1C6 (ECACC No. 1C6 90050301). The antigen may be used to diagnose diabetes in a patient.
申请公布号
DE69122864(D1)
申请公布日期
1996.11.28
申请号
DE1991622864
申请日期
1991.05.06
申请人
RIJKSUNIVERSITEIT TE LEIDEN, LEIDEN, NL
发明人
ROEP, BART, OTTO RIJKSUNIVERSITEIT TE LEIDEN, NL-2312 AV LEIDEN, NL;DE VRIES, RENE, RUDOLF, PIETER, NL-2312 AV LEIDEN, NL;HUTTON, JOHN, CHARLES RIJKSUNIVERSITEIT TE LEIDEN, NL-2312 AV LEIDEN, NL
