VACCINE COMPOSITION CONTAINING POLYRIBOSYLRIBITOL PHOSPHATE AND METHOD FOR MAKING SAME

摘要

A vaccine composition containing one or more antigens comprising the high molecular weight capsular polysaccharide of type b Haemophilus influenza, or polyribosylribitol phosphate, coupled to the tetanus toxoid and an aluminium-based adjuvant, wherein the aluminium-based adjuvant has, in its natural state, or following anion addition, a zero point of charge of less than about 7.2. A method for making said vaccine composition is also described.