NOVEL CEPHEM DERIVATIVES

摘要

Compounds represented by general formula (I) and having a beta -(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad antimicrobial spectrum and exerts potent antimicrobial effects on Gram-positive bacteria, Gram-negative bacteria and even resistant bacteria. In formula (I) X represents CH or N; R<1> represents hydrogen or an amino protecting group; R<2> represents hydrogen, C1-6 alkyl, C3-7 cycloalkyl or a hydroxy protecting group; R<3> is not present or represents hydrogen, a cation forming a salt or a carboxy protecting group; R<4>, R<5> and R<6> may be the same or different and each represents hydrogen or C1-6 alkyl; R<7+> is not present or represents a cation of C1-6 alkyl; and n is an integer of 0 or 1.