发明名称 |
PREPARATION OF ARALKANOIC ACIDS AND ESTERS USING MIXED LIGAND CATALYST |
摘要 |
The activity of a palladium catalyst in the carboxylation of an aralkene with carbon monoxide and water or an alcohol in the absence of oxygen can be enhanced when it is used in conjunction with (A) a ligand mixture comprising compounds corresponding to the formulas R3ZY and R'3Z wherein each R and R' is independently selected from alkyl, aryl and substituted aryl groups; Y is a member of Group VIA of the Periodic Table; and Z is an element having a Pauling electronegativity of 1.9-2.5 or (B) a complex ligand providing all of the elements of said mixture. The invention has particular utility in carboxylating an aralkene such as 4-isobutylstyrene or 2-methoxy-6-vinylnaphthalene to ibuprofen or naproxen or their esters; and the preferred novel ligand is usually a 50/50 mixture of phosphine and phosphine oxide.
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申请公布号 |
CA2222020(A1) |
申请公布日期 |
1996.11.28 |
申请号 |
CA19952222020 |
申请日期 |
1995.05.23 |
申请人 |
ALBEMARLE CORPORATION |
发明人 |
WU, TSE-CHONG |
分类号 |
B01J31/22;B01J31/24;C07C51/14;C07C57/30;C07C57/40;C07C67/38;C07C69/612;C07C69/616;(IPC1-7):C07C57/30;C07D207/20;C07D333/24;C07D209/46;C07D263/57;C07C59/64 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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