| 摘要 |
The invention is a choline feed stock precursor having greater than about 80-wt % of choline chloride, a lubricating agent, and an excipient. Generally, the composition of the invention may comprise a choline compound at concentrations above 80 wt-%, trace amounts of lubricating agent, and an excipient. To extend shelf-life, a hydrophobic stabilizing agent or adjuvant may be added to the composition of the invention. This preferred composition remains free-flowing when subjected to ambient conditions of up to 49 DEG C. and less than 90% relative humidity. The invention is also a process for formulating choline feed stock precursors, having greater than about 80-wt % choline chloride. The method of the invention generally includes the steps of inter-mixing choline and an excipient, spray drying this mixture in the presence of a lubricating agent and adding an additional portion of hydrophobic stabilizing agent, to the mixture. |
