USE OF FLAVANOLIGNANES FOR THE PREPARATION OF MEDICAMENTS WITH ANTIPROLIFERATIVE ACTIVITY IN UTERUS, OVARY AND BREAST

摘要

The invention relates to the use of flavanolignanes such as silymarin, silybin, silidianin, silicristin, mixtures thereof, extracts and formulations containing them, in the therapy (and prophylaxis) of uterus, ovary and breast tumors. These flavanolignanes have already been used in therapy for the treatment of hepatopathias of different origin, and they surprisingly show a marked affinity to the estrogen receptors of type II and an antiproliferative activity on tumor cell lines of uterus, ovary and breast.