发明名称 |
METHOD FOR TREATMENT OF SLE |
摘要 |
Treatments have been developed for lupus patients using either anti-ID antibodies to dsDNA to block anti-dsDNA antibodies and/or kill the B cells producing the anti-dsDNA antibodies or ribosomal protein S1 peptides immunoreactive with anti-dsDNA antibodies. Examples demonstrate that (1) anti-dsDNA antibodies are cross-reactive with ribosomal protein S1, (2) anti-dsDNA antibodies suppress protein synthesis, presumably through inhibition of mRNA translation initiation, and (3) a normal human sera contains an anti-idiotypic antibody (anti-Id) to anti-dsDNA antibodies isolated from SLE patients which blocked the interactions between the anti-Id antibody fragment (Fab2) and various anti-dsDNA preparations.
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申请公布号 |
WO9637225(A1) |
申请公布日期 |
1996.11.28 |
申请号 |
WO1996US07597 |
申请日期 |
1996.05.24 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
REICHLIN, MORRIS;TSUZAKA, KENSEI;ZHANG, WEI |
分类号 |
A61K38/00;C07K14/47;C07K16/42;(IPC1-7):A61K39/395;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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