| 发明名称 |
ANTIGEN-SPECIFIC ACTIVATION OF UNPRIMED CD8+ T CELLS |
| 摘要 |
An artificial antigen-presenting system provides methods and compositions for the activation of unprimed CD8+ T cells in vitro to form specific activated CD8+ T cells (cytotoxic T lymphocytes, or CTL). CD8+ T cells are activated by contacting them with macrophages that present a MHC molecule complexed to an immunogenic peptide, acquired by phagocytosis of the peptide on an artificial support and with an assisting molecule.
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| 申请公布号 |
WO9637107(A1) |
申请公布日期 |
1996.11.28 |
| 申请号 |
WO1996US07436 |
申请日期 |
1996.05.22 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
DEBRUIJN, MARLOES, L., H.;JACKSON, MICHAEL, R.;PETERSON, PER, A. |
| 分类号 |
A61K38/00;C07K14/115;C07K14/145;C07K14/725;C07K14/77;C12N5/0783;(IPC1-7):A01N63/00;A01N65/00;A01N1/00;A01N1/02;A61K35/12;A61K35/14;C12N5/00;C12N5/02;C12N5/08;C12N11/00;C07K7/00;C07K9/00;C07K11/00;C07K1/04;C07K17/00;C07K17/02 |
主分类号 |
A61K38/00 |
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