Actinomycetepromoter

摘要

A 1 kbp length of the 5'-noncoding region of the gene encoding cytochrome P-450sca-2 in the actinomycete Streptomyces carbophilus has transcription promoter activity which is substrate inducible. When the 1 kbp region is shortened, transcription activity becomes constitutive and the shortened promoters can be used advantageously in expression systems, especially those expressing P-450sca-2 in the presence of ML-236B to produce pravastatin sodium.