发明名称 |
CHIMERIC FATTY BODY-PRO-GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY |
摘要 |
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include a hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
|
申请公布号 |
CA2222068(A1) |
申请公布日期 |
1996.11.28 |
申请号 |
CA19962222068 |
申请日期 |
1996.05.22 |
申请人 |
THERATECHNOLOGIES INC. |
发明人 |
ABRIBAT, THIERRY;IBEA, MICHEL;BRAZEAU, PAUL |
分类号 |
A61K38/00;A61K38/22;A61P3/02;A61P5/02;A61P43/00;C07K14/60;C07K19/00;G01N33/68;(IPC1-7):C07K14/60;A61K49/00;A61K38/25 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|