In vivo binding pair pretargeting

摘要

PCT No. PCT/US93/01858 Sec. 371 Date Nov. 4, 1993 Sec. 102(e) Date Nov. 4, 1993 PCT Filed Mar. 3, 1993 PCT Pub. No. WO93/17707 PCT Pub. Date Sep. 16, 1993A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.