PROCESS FOR PRODUCING LOWER ALKYL-ESTERS OF PYRIMIDO-BRACKET-4,5-B-BRACKET CLOSED-QUINOLIME-4-BRACKET-3H-BRACKET CLOSED-ONE-2-CARBOXYLIC ACIDS

摘要

The cyclization of 2-aminoquinoline-3-carboxamide and nuclear substituted derivatives thereof with a dialkyl:oxalate in the presence of a sodium alkoxide or other suitable base under mild conditions to produce alkyl pyrimido¢4,5-b!quinolin-4(3H)-one-2-carboxylates. The products are useful as antiallergy agents.