IMMUNOCONJUGATES COMPRISING SINGLE-CHAIN VARIABLE REGION FRAGMENTS OF ANTI-CD-19 ANTIBODIES

摘要

Disclosed are polynucleotides encoding single chain variable region fragments of a monoclonal antibody to CD19 and methods for preparing the same. Also disclosed are single chain variable region polypeptides, methods for preparing the same, point modified polypeptides, and dimers derived therefrom. An additional aspect of the invention discloses immunoconjugates formed between a polypeptide of the invention and cytotoxic agents, as well as methods for their preparation, as well as use in the treatment of cancer.