METHOD FOR DERIVING RIBOZYMES FROM NUCLEOTIDE SEQUENCES AND RIBOZYMES DERIVED THEREOF
摘要
A method for the identification by modeling of synthetic catalytic RNAs and ribozymes thereof are disclosed including a hairpin portion and binding sites for cleaving an RNA substrate at a site which has a GUA sequence following the site of cleavage. Synthetic catalytic RNA has been modeled from negative strands of satellite RNA from the group consisting of chicory yellow mottle virus (sCYMVI) and arabis mosaic virus (sArMV).
申请公布号
WO9636353(A1)
申请公布日期
1996.11.21
申请号
WO1996US06596
申请日期
1996.05.09
申请人
NORTHERN ILLINOIS UNIVERSITY - BOARD OF TRUSTEES;DEYOUNG, MARY, BETH;SIWKOWSKI, ANDREW, M.;HAMPEL, ARNOLD, E.
发明人
DEYOUNG, MARY, BETH;SIWKOWSKI, ANDREW, M.;HAMPEL, ARNOLD, E.