发明名称 TETRALIN COMPOUNDS WITH MDR ACTIVITY
摘要 The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for the use in multi-drug resistant cancer. These compounds are represented by general formula (I), in which the different substitutes are defined into the description.
申请公布号 CA2219752(A1) 申请公布日期 1996.11.21
申请号 CA19962219752 申请日期 1996.05.16
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 ZELLE, ROBERT E.
分类号 A61K31/44;A61K31/4427;A61K31/445;A61P35/00;A61P43/00;C07C45/46;C07C45/71;C07C49/755;C07C59/68;C07D213/30;C07D401/12;(IPC1-7):C07D401/12;C07D473/00;C07D475/00;C07D455/02;C07D471/04;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D333/24;C07D217/26;A61K31/435;A61K31/495;A61K31/53;A61K31/535;C07D213/54;C07D307/54;A61K31/54;C07D211/60 主分类号 A61K31/44
代理机构 代理人
主权项
地址