发明名称 |
CELL DEATH PROTEIN |
摘要 |
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis. |
申请公布号 |
WO9636730(A1) |
申请公布日期 |
1996.11.21 |
申请号 |
WO1996US05386 |
申请日期 |
1996.04.18 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE GENERAL HOSPITAL CORPORATION |
发明人 |
LEDER, PHILIP;SEED, BRIAN;STRANGER, BEN, Z.;LEE, TAE-HO;KIM, EMILY |
分类号 |
G01N33/48;A61K38/00;A61K48/00;C07K14/46;C07K14/715;C07K16/18;C07K16/24;C12N5/10;C12N9/12;C12N15/09;C12P21/02;C12P21/04;C12P21/08;C12Q1/02;C12R1/91;G01N33/15;G01N33/577 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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