N-(3-AMINOPROPYL)-N-PHENYL-5,6,7,8-TETRAHYDRONAPHTHALENE- 2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN THERAPY

摘要

FIELD: medicine. SUBSTANCE: claimed invention describes compounds of general formula (I):wherein Ris hydrogen or halogen atom, either methyl or C-Calkoxy group; hydrogen or halogen atom;is hydrogen atom or methoxy group; C-Cis alkyl group; Ris 2,3- dihydroxy-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl, or 1,2,3,4-tetrahydronaphthalen-1-yl group, or alternatively Rand Rtogether with nitrogen atom form 1,2,3,4- tetrahydroisoquinolin-2-yl, 6,7-dimethoxy, 1,2,3,4- tetrahydroisoquinolin-2-yl, 5,8-dimethoxy-1,2,3,4- tetrahydroisoquinolin-2-yl, 1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido (4,3-b) indol-3-yl, 4,5,6,7-tetrahydrothieno (2,3-c) pyrid-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetrahydro-1H-3- benzazepin-3-yl group. EFFECT: improved properties of the title compounds.