摘要 |
Benzopyran derivatives of formula (I), wherein X<1> and X<2> are absent or represent an oxygen atom; X represents an oxygen atom, a sulfur atom, a nitrogen atom (said nitrogen atom is unsubstituted or substituted by a hydrogen atom or C1-C4 alkyl group), carbonyl or thiocarbonyl; A represents a hydroxyl group or may form a single bond together with B; B represents a hydrogen atom or may form a single bond together with A; Y represents 1-pyrrolyl group, 1-pyrazolyl group, 1-imidazolyl group, 1-(1,2,3-triazolyl) group or 1-(1,2,4-triazolyl) group which is unsubstituted or substituted by R<3>; R<1> and R<2> independently represent a hydrogen atom, a phenyl group or a C1-C4 alkyl group; R<3> represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and medicines for treating cardiac insufficiency containing said compound as an active ingredient. The compounds have a strong activity of reinforcing the contraction of cardiac muscles and a strong activity of reducing the heart rate. As the compounds are not toxic, they are useful medicines for treating cardiac insufficiency. |