| 摘要 |
A process of preparing a dihydropyrimidine compound of the structure (I): <IMAGE> wherein R1 and R2 are bonded together to form an aromatic or heterocyclic ring, which may be substituted or unsubstituted, or are individually selected from the group consisting of hydrogen, or a substituted or unsubstituted aliphatic, carbocyclic, or heterocyclic group; R3, R4 and R5 are individually selected from the group consisting of hydrogen or a substituted or unsubstituted aliphatic, carbocyclic or heterocyclic group; and X represents the atoms necessary to form a 5 or 6 membered heterocyclic ring, and is selected from the group consisting of oxygen, sulfur, selenium, <IMAGE> wherein R6, R7, and R8 are individually selected from the group consisting of a substituted or unsubstituted aliphatic, carbocyclic or heterocyclic group; comprising combining a compound (A) of the structure: <IMAGE> wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as previously defined, with a catalytic amount of a Group 11 or 12 metal cation catalyst at a temperature of less than about 50 DEG C. and in the presence of an organic solvent, to form compound (I).
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