发明名称 |
Controlled release tacrine drug delivery systems and methods for preparing same |
摘要 |
The present invention pertains to controlled release tacrine drug delivery systems comprising an immediate release composition and a sustained release composition wherein (1) the immediate release composition comprises in percentages by weight of the immediate release composition: (A) immediate release pellets comprising: (a) nonpareil seeds in an amount from about 25% to about 75%; (b) tacrine in an amount from about 10% to about 80%; and (c) a binding agent in an amount from about 1% to about 10%; and (B) a sealing layer over the immediate release pellets comprising: (a) a sealing agent in an amount up to about 6%, and (b) a first plasticizing agent in an amount up to about 5%; and (2) the sustained release composition comprises in percentages by weight of the sustained release composition; (A) the immediate release composition; and (B) a sustaining layer over the immediate release composition comprising; (a) a water-insoluble polymer in an amount from about 40% to about 90%; (b) a water-soluble polymer in an amount up to about 10%; and (c) a second plasticizing agent in an amount up to about 10%; wherein the sustaining layer and the immediate release composition are present in the sustained release composition in a ratio by weight from about 1:9 to about 4:6, respectively, and the immediate release composition and the sustained release composition are present in the drug delivery system in a ratio by weight from about 0.01:1 to about 1:1, respectively.
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申请公布号 |
US5576022(A) |
申请公布日期 |
1996.11.19 |
申请号 |
US19950422019 |
申请日期 |
1995.04.12 |
申请人 |
WARNER LAMBERT COMPANY |
发明人 |
YANG, S. SHIRLEY;BOISVERT, WAYNE;MUHAMMAD, NOUMAN A.;WEISS, JAY |
分类号 |
A61K9/00;A61K9/16;A61K9/50;A61K9/56;A61K31/47;(IPC1-7):A61K9/24 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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