发明名称 |
Gastrointestinal mucosa-adherent matrixes, pharmaceutical preparations and a coating composition |
摘要 |
A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.
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申请公布号 |
US5576025(A) |
申请公布日期 |
1996.11.19 |
申请号 |
US19950412591 |
申请日期 |
1995.03.29 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
AKIYAMA, YOHKO;NAGAHARA, NAOKI;HIRAI, SHIN-ICHIRO |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K9/48;A61K9/50;A61K9/58;A61K31/44;A61K47/12;A61K47/14;A61K47/32;A61K47/34;A61K47/38;A61K47/44;A61P1/00;A61P1/04;A61P31/04;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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