Process for the preparation of amidino phenyl pyrrolidine beta -alanine urea analogs

摘要

The invention herein is directed to a process for producing a lactam of the formula <IMAGE> from a methionine analog of the formula <IMAGE> by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent. The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl beta -alanine urea analogs using such methionine and lactam compounds as intermediates, which beta -alanine urea analogs are useful as antithrombotics.