| 摘要 |
PCT No. PCT/GB96/00958 Sec. 371 Date Sep. 26, 1997 Sec. 102(e) Date Sep. 26, 1997 PCT Filed Apr. 23, 1996 PCT Pub. No. WO96/33977 PCT Pub. Date Oct. 31, 1996The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R2 is independently halogeno; and R1 is di-[(1-4C)alkyl]amino-(2-4C)alkoxy, pryolidin-1-yl-(2-4C)alkoxy,piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer. |
