摘要 |
<p>Novel physiologically active NA23063 analogues and pharmacologically acceptable salts thereof. Microorganisms belonging to the genus Streptomyces and capable of producing physiologically active substances NA23063A, B1, B2, C and D are incubated in a medium and the physiologically active substances NA23063A, B1, B2, C and D thus accumulated in the culture are collected. These compounds are further converted into derivatives thereof. For example, structure (I) of NA23063D is as above. Because of having the effect of inhibiting phosphodiesterases, the compounds are useful as the active ingredient of, for example, an antiasthmatic agent, a bronchodilator, a remedy for bronchitis, an antiallergic agent, an anti-inflammatory agent, an antirheumatic agent, a hypotensive drug, a remedy for angina pectoris, a remedy for arrhythmia, a cerebral vasodilator, a blood coagulation inhibiting agent or an antidepressant agent.</p> |