发明名称 |
METHOD FOR PREPARING AN OPTICALLY PURE BENZOFURAN CARBOXYLIC ACID AND USE THEREOF FOR PREPARING EFAROXAN |
摘要 |
A novel method for preparing an optically pure 2-ethyl-2,3-dihydro-benzofurancarboxylic acid derivative of general formula (II) is described, wherein R is a hydrogen atom, a halogen, a lower alkyl, lower alkoxy or hydroxy radical. The method comprises separating the racemic mixture by selective crystallisation with the suitable optically pure enantiomer of 2-phenylglycinol, in a suitable solvent, whereafter the optically pure, crystallised acid of formula (II) is isolated and recovered. The invention also provides the optically pure 2-ethyl-2,3-dihydro-benzofurancarboxylic acid derivative thus obtained and the use thereof for the preparation of an optically pure derivative of efaroxan.
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申请公布号 |
WO9635682(A1) |
申请公布日期 |
1996.11.14 |
申请号 |
WO1996FR00697 |
申请日期 |
1996.05.09 |
申请人 |
PIERRE FABRE MEDICAMENT;IMBERT, THIERRY;MAYER, PATRICK |
发明人 |
IMBERT, THIERRY;MAYER, PATRICK |
分类号 |
C07D307/85;C07D405/04;(IPC1-7):C07D307/85 |
主分类号 |
C07D307/85 |
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