The field of the invention is recombinant packaging and producer cell lines for producing infectious retroviral vectors. The invention more specifically relates to the generation of pseudotyped retroviral vectors with a broad host range which can be produced at high titers in specially constructed packaging cell lines. Most specifically, the invention relates to the generation of pseudotyped retroviral vectors having vesicular stomatitis virus-G protein (VSV-G) as the membrane-associated viral envelope protein.
申请公布号
WO9635454(A1)
申请公布日期
1996.11.14
申请号
WO1995US12428
申请日期
1995.09.06
申请人
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;GENETIC THERAPY, INC.
发明人
YANG, YANPING;VANIN, ELIO, F.;GROSVELD, GERARD, C.;NIENHUIS, ARTHUR, W.