| 发明名称 |
NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES |
| 摘要 |
Compounds having formula (I) wherein R1, R5, R6 and R7 are hydrogen or certain specified substituents; R8 and R9 are independently hydrogen, hydroxy or alkoxy; and X, A and B are independently NR2, O, S, SO, SO2, CH=CH or (CH2)p, p being 0-6; are useful as nitric oxide synthase inhibitors.
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| 申请公布号 |
CA2218360(A1) |
申请公布日期 |
1996.11.14 |
| 申请号 |
CA19962218360 |
申请日期 |
1996.05.09 |
| 申请人 |
G.D. SEARLE & CO.;G.D. SEARLE & CO. |
发明人 |
HALLINAN, E. ANN;TJOENG, FOE S.;SPANGLER, DALE P.;BERGMANIS, ARIJA A.;TOTH, MIHALY V.;HANSEN, DONALD W., JR.;WEBBER, R. KEITH;METZ, SUZANNE;PETERSON, KAREN B.;FOK, KAM F.;TSYMBALOV, SOFYA;PITZELE, BARNETT S.;KRAMER, STEVEN W.;HAGEN, TIMOTHY J. |
| 分类号 |
A61K31/00;A61K31/40;A61K31/445;A61K31/55;A61P9/00;A61P9/02;A61P31/00;A61P37/00;A61P37/06;C07D207/22;C07D207/24;C07D211/72;C07D211/74;C07D223/12;C07D243/08;C07D267/08;C07D267/10;C07D403/06;C07D413/06;C07D413/12;C07D471/10;(IPC1-7):C07D223/12;C07D401/00;C07D403/00;C07D405/00;C07D409/00;C07D413/00;C07D417/00;C07D281/06;A61K31/395;C07F9/547;A61K31/675 |
主分类号 |
A61K31/00 |
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