摘要 |
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R4 is selected from the group consisitng of -H or-NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R6 is selected from the group consisting of -H, or halo (preferably -Cl); with the overall proviso that R4 and R6 are not both -H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. |
申请人 |
PHARMACIA & UPJOHN COMPANY;NUGENT, RICHARD, A.;WISHKA, DONN, G.;CLEEK, GARY, J.;GRABER, DAVID, R.;SCHLACHTER, STEPHEN, THOMAS;MURPHY, MICHAEL, J.;MORRIS, JOEL;THOMAS, RICHARD, C. |
发明人 |
NUGENT, RICHARD, A.;WISHKA, DONN, G.;CLEEK, GARY, J.;GRABER, DAVID, R.;SCHLACHTER, STEPHEN, THOMAS;MURPHY, MICHAEL, J.;MORRIS, JOEL;THOMAS, RICHARD, C. |