1-Carba (1-dethia) -cephem antibiotics and pharmaceutical compositions containing them

摘要

Various 3-substituted 1-carba(1-dethia)-3-cephems, useful as antibacterial agents are provided. Also provided are pharmaceutical compositions comprising same and methods for treating bacterial infections in man and other animals. An antibacterial compound of the formula wherein R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, or C1-C6 haloalkyl; A and A min are independently hydrogen, C1-C6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2 or 3 hetero atoms selected from nitrogen or sulfur, C1-C6 alkoxy or phenyl; or A and A min taken together from a group of the formulae wherein X is hydrogen, halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof.