发明名称 |
Prepn. of 3-aryl-quinazolin-2,4-di:one derivs., useful as intermediates for pharmaceuticals and plant-protecting agents |
摘要 |
Prepn. of substd. 3-arylquinazolin-2,4-diones of formula (I) comprises: (A) reacting a nitro cpd. of formula (II) with an anthranilic acid deriv. of formula (III) and carbon monoxide in the presence of a catalyst, a ligand and a solvent to give (I); or (B) (a) reacting (II) with an alcohol of formula R10OH (IV) and carbon monoxide in the presence of a catalyst, a ligand and a solvent to give a carbamate of formula (V); and (b) treating (V) with (III) in the presence of a base and in an aprotic solvent to give (I): R1-R4 = H, halo, 1-12C alkyl, 1-12C alkoxy, Ar or ArO; Ar = a gp. of formula (a); R5-R9 = H, halo, 1-12C alkyl, 1-12C alkoxy, phenyl, phenoxy or any pair of adjacent R groups may form an additional aromatic ring; and R10 = 1-12C alkyl.
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申请公布号 |
DE19517035(A1) |
申请公布日期 |
1996.11.14 |
申请号 |
DE19951017035 |
申请日期 |
1995.05.10 |
申请人 |
HOECHST AG, 65929 FRANKFURT, DE |
发明人 |
WEIGUNY, JENS, DR., 64331 WEITERSTADT, DE;BORCHERT, HOLGER, DR., 65929 FRANKFURT, DE;GERDAU, THOMAS, DR., 65817 EPPSTEIN, DE |
分类号 |
C07D239/96;(IPC1-7):C07D239/96;C07D239/70;B01J23/40;B01J23/74;B01J31/28 |
主分类号 |
C07D239/96 |
代理机构 |
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