USE OF(S)-ENANTIOMERS OF 1,4-DIHYDROPYRIDINE DERIVATIVES FOR TREATING HEART FAILURE

摘要

(S)-enantiomers of compounds (I), (Ph = phenyl, Ar = 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A = a C3-C6 branched chain alkylene group, R = C1-C6 alkyl optionally mono-substituted by C1-C6 alkoxy, R1 = H, OH or C1-C4alkyl, R2 = H or CH3) have a positive inotropic effect on cardiac contractility and are useful in the treatment of heart failure and in the preparation of medicaments for use in such treatments. The preparation of the (S)-enantiomers is also described.